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Clinical data [Study on effectiveness and safety of Lagerstroemia speciosa L.]
Mechanism at molecule level and others
Clinical studies in the Philippines and India
Work schedule of extract manufacture
Various animal experiments
Harvest data of banaba leaves
Analysis data of banaba food ingredient
Certification of long history of banaba as food in the Philippines
Certification of export records of 1993 and previous year [from the Philippines to the U.S. and Europe]
UTC profile
Information disclosure
UTC’s lines of business
VTR, CD for publicity
Certificate of Analysis
Product Specifications
US Patent Claim Forms
LATEST RESEARCH
Chemical Study of the Leaves of Banaba Lagerstroemia Speciosa Linn. *NEW*
Plantisul Tablets in the Treatment of Diabetes Mellitus. *NEW*
Pharmaceutico-Chemical and Pharmacological studies on a crude drug from Lagerstroemia Speciosa (L.) Pers. *NEW*
The Cytotoxic Principles of Hyptis Capitata and the Structures of of the new Triterpenes Hyptatic Acid -A and -B *NEW*
Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica. *NEW*
Tannins and related compounds. CVI. *NEW*
Tannins and related compounds. CVII. *NEW*
Tannins and related compounds. CXVII. *NEW*
Ellagitannins from Lagerstroemia Speciosa as Activators of Glucose Transport in Fat Cells. *NEW*
Corosolic Acid Isolated from the fruit of Crataegus pinnatifida var. *NEW*
Antiobesity Activity of Extracts from Lagerstroemia Speciosa L. Leaves on Female KK-A Mice. *NEW*
An extract of Lagerstroemia Speciosa L. has Insulin-like Glucose Uptake-Stimulatory and Adipocyte Differentiation-Inhibitory activities in 3T3-L1 Cells. *NEW*
 
 
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No. Experimenter and place
Name of Journal
R-1

"The Clinical Study on the Corosolia BW for mild cases of diabetes mellitus"

Experimenter: Then Prof. Yoshio Ikeda of Tokyo Jikeikai Medical University, Dr. Jui-Tung Chen of J. T. Chen Clinic and Dr. Takemi Matsuda of Aiwa Clinic.

Place: J. T. Chen Clinic and Aiwa Clinic (hot water extract)

Japanese Parmacology & Therapeutics (February 1999)

R-2

figure

Table

Effectiveness and Safety in administering Banaba Extract to “those who are concerned about blood sugar levels”

Experimenter: Dr. Yoshio Ikeda and Big S

Place: Hibiya Hospital and others (alcohol extract)

Practice (June 2001)
R-3 Experimenter: Dr. Yoshio Ikeda and Big S

Trial on safety of side effects in patients taking SU (alcohol extract)

A journal issued by Japan Health Food & Nutrition Food Association (March 2002)
R-4

The Cytotoxic Principles of Hyptis Capitata and the structures of the new Triterpenes Hyptatic Acid-A and -B *NEW*

Experimenter: Takashi Yamagishi, De-Cheng Zhang, Jer-Chang, etc.

Place: United States

Phytochemistry
R-5

Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica. *NEW*

Experimenter: Nunziatina De Tommasi, Francesco De Simone, Gluseppe Cirino, Carla Cicala, and Cossimo Pizza.

 
R-6

Tannins and related compounds. CVI. *NEW*

Experimenter: Ya-Ming Xu, Takashi Sakai, Takashi Tanaka, Gen-Ichiro Nonaka, and Itsuo Nishioka

Place: Shanghai Institute of Materia Medica

Chemical Pharmacy Bulletin
R-7

Tannins and related compounds. CVII. *NEW*

Experimenter: Ya-Ming Xu, Takashi Tanaka, Gen-Ichiro Nonaka, and Itsuo Nishioka

Chemical Pharmacy Bulletin

R-8

Tannins and related compounds. CXVII. *NEW*

Experimenter: Takashi Tanaka, Hui-Hong Tong, Ya-Ming Xu, Kanji Ishimaru, Gen-Ichiro Nonaka, and Itsuo Nishioka.

Chemical Pharmacy Bulletin
R-9

Ellagitannins from Lagerstroemia Speciosa as Activators of Glucose Transport in Fat Cells. *NEW*

Experimenter: Takeo Hayashi, Haruko Maruyama, Royji Kasai, Katsuji Hattori, Shunsuke Takasuga, Osamu Hazeki, Kazuo Yamasaki and Takashi Tanaka.

Planta Med
R-10

Corosolic Acid Isolated from the fruit of Crataegus pinnatifida var. *NEW*

Experimenter: Kyung-Seop Ahn, Moon Sun Hahn, Eun Jin Park Hyeong-Kyu Lee and Ik-Hwan Kim

Planta Med
R-11 Antiobesity Activity of Extracts from Lagerstroemia Speciosa L. Leaves on Female KK-A Mice. *NEW* J. Nutr Sci Vitaminol

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No. Subject compound
Experimenter Content of experiment and date of issue
M-1 Corosolic acid (ethanol)
"Screening of Plant Constituents for Effect on Glucose Transport Activity in Ehrlich Ascites Tumour Cells"

Prof. Kazuo Yamasaki, Hiroshima University

Glucose transport activity of corosolic acid in Ehrlich ascites tumor cells

M-2

Corosolic acid (ethanol)
"Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxvlated Triterpenoids of Eriobotrya japonica"

Italy

Glucose transport activity of corosolic acid
M-3 Corosolic acid (ethanol)
Dr. Toshihiro Miura
Animal experiment with simple corosolic acid

By making the absorption better, the activity was seen.

M-4 Extraction and activity of ellagitannin
Prof. Kazuo Yamasaki, Hiroshima University Identify Lagerstroemin and three other substances by hot water and hexane.
M-5 Mechanism of ellagitannin
Prof. Osamu Hazeki, Hiroshima University Insulin signaling transport of Lagerstroemin in adipose cells
M-6 Water extract "Hypogycemic Effect of Extract from Lagerstroemia speciosa L. Leaves in Genetically Diabetic KK-A y Mice"

Dr. Takami Kakuda, Central Institute, Ito En Ltd.

Effect on blood glucose level of sugar absorption inhibition

Animal experiment

M-7 Water extract Prof. Takeuchi, Faculty of Agriculture, Shizuoka University Control blood glucose level rise by sugar absorption inhibition
M-8 Alcohol Extract Dr. Williams Judy

Experiment on Glucosol (banaba extract & DHA) in soft gelatin capsule formulation


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No. Experimenter
Contents of Experiments
P-1

Dr. Faustino Garcia

"Distribution and Deterioration of Insulin-Like Principle in Lagerstroemia Speciosa"

Philippine General Hospital

P-2

Dr. Faustino Garcia

"On the Hypoglycemic Effect of Decoction of Lagerstroemia Speciosa Leaves Administered orally"

Philippine General Hospital

T-1

Clinical study in India

"Hypoglycamic Activity of Leaves of Lagerstroemia Speciosa(L)Pers."

Hamdaed College of Pharmacy and College of Pharmacy, University of Delhi, Delhi.

P-3 Bernadita A. Alonza

Chemical Study of the Leaves of Banaba Lagerstroemia Speciosa Linn. *NEW*

P-4 Dr. Faustino Garcia Plantisul Tablets in the Treatment of Diabetes Mellitus. *NEW*
P-5 Dr. Faustino Garcia Pharmaceutico-Chemical and Pharmacological studies on a crude drug from Lagerstroemia Speciosa (L.) Pers. *NEW*

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No. Extract
 
E-1

Hot water extract

Maruzen Pharmaceuticals Co., Ltd.
E-2

Ethanol extract

Maruzen Pharmaceuticals Co., Ltd., Tokiwa Phytochemical Co., Lt.

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No. Title of paper
A-1 "Investigation of the Effects of COROSOLIA PBA on Blood Sugar Increase in Streptozotocin-Induced Diabetic Rats"

Control blood glucose level rise by banaba extract and safety

A-2-a

"Investigation of the hypoglycemic effects of Glucosol aerosol in rats"

Study on controlling blood glucose level rise with atomization of banaba extract

A-2-b "Investigation of the hypotriglyceric and hypoglycemic effects of Banaba transparent extract aerosol in STZ-induced diabetic rat"

Study on controlling blood glucose level rise with atomization of banaba extract

A-3

"Investigation of hypoglycemic effects of Glucosol in STZ-induced diabetic rats in comparison with oral anti-diabetic agents"

Comparative trial on effect of banaba and other oral medicine for diabetes

A-4

"Investigation of the hypotriglyceric, hypoglycemic and hypotensive effects of Banaba tobacco smoke in STZ-induced diabetic rats"

Study on banaba tobacco

A-5

"A Single Dose Toxicity Study of Corosolia PBA on Rat"

Single oral dose toxicity study


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No. Content
B-1

A Chart illustrating the flow of banaba harvest from harvest, cleaning, drying, sorting, sacking (cutting) to boarding

B-2

A list of banaba suppliers in the Philippines. Data of 5 million numbered banaba trees.

B-3 Distribution date of banaba (Lagerstroemia speciosa) in Southeast Asia

Difference between banaba varieties examined by DNA

B-4

Distribution map of native banaba trees in Southeast Asia, Australia and India (Data analyzed from satellite photographs)


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No. Data
F-1

Analysis result of Banaba done by Japan Food Research Laboratories

F-2

Analysis result of Banaba seeds

F-3-a Analysis result of Banaba extract ( BA )
F-3-b Analysis result of Banaba extract ( BW )
F-4 Nutrition analysis table of Banaba tea
F-5-a Food composition analysis result of Banaba-fit
F-5-b

Food composition analysis result of Banaba-min


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No. Content
H-1

Certifications of long history of banaba as food issued by representatives of various organizations in the Philippines ( Department of Trade and Industry, CITEM , ATENEO )


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No. A copy of certification of export records to the U.S. and Europe
N-1

It simplifies import and export.


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No. Experimenter and place
Name of Journal
P-1

Company history

P-2

Company profile


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No. Account settlement and shareholders
D-1 Account settlements of 1999, 2000 and 2001
D-2 Shareholder list and shareholder ratio table (UFJ Trust Bank)

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No. Product name, definition, product no.
S-1 COROSOLia BW, Banaba hot water extract, specification
S-2 COROSOLia BA, Banaba alcohol extract, specification
S-2 Banaba powder BP, Banaba sterilized powder, specification
S-4 Whole banaba leaves B-30, 30kg of dried leaves harvested for tea, specification
S-5 Corosolic acid standard (reagent) 90%, specification
S-6 Ellagitannin standard (Lagerstroemin) 90%, specification
S-7 COROSOLia 1000 (Gulcoba). Extract contains more than 10% of corosolic acid, specification
S-8 Largerst 100(Ellagiba). Extract contains more than 1% of Lagerstroemin, specification

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No. Content
V-1 Futoshi Matsuyama in the Philippines
V-2 Japanese programs such as “Aru-Aru Dai-Jiten”
V-3 UTC character, “Buko King” show

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No. Product name
C-1 Corosolia M (Lot No.: 40905005)
C-2 Banaba leaves
C-3 Corosolia PBA (Lot No.: 40316007)
C-4 Corosolia PBA (Lot No.: 40628008)
C-5 Corosolia PBA (Lot No.: 40722009)
C-6 Corosolia PBA (Lot No.: 40722010)
C-7 Corosolia PBA (Lot No.: 41219011)
C-8 Corosolia PBA (Lot No.: 50120012)

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No. Product name
D-1 Corosolia M
D-2 Corosolia PBA
D-3 Corosolia PBW

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No. Patent NO.
U-1 US 6, 485, 760

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No. Content of Clinical Studies
R-1 The Clinical Study on Corosolia BW
R-2 Insuline Secretion and Insuline Sensitivity at differents stages
R-3 Natural Products and Medicinal Plant Research
R-4 Triterpene Acids from the leaves of Perilla futescens
R-5 Antidiabetic activity of a standardized extract