Use Techo Corporation, Effectiveness of Banaba, Banaba has natural mineral such as magnesium and zinc which help metabolism of sugar.

In 1998, a clinical trial conducted under the supervision of Prof. Yoshio Ikeda of Tokyo Jikeikai Medical University, Health and Medical Center. In the trial, “BanabaMin Tablets” containing 95? water extract from banaba was tested and significant reduction of mean blood glucose level of subjects was observed. The mean blood glucose level dropped from 153.9 to 133.1 over 4 weeks. This trial scientifically proved that banaba lowers blood glucose level.

Yoshio Ikeda, Tokyo Jikeikai Medical University, Health and Medical Center
Jui-Tung Chen, J. T. Chen Clinic
Takemi Matsuda, Aiwa Clinic
Japan Pharmacology & Therapeutics Vol.27 NO.5 99

Lagerstroemia speciosa L. (LSL) and Japonica have applied for diabetes mellitus (DM) as a pharmaceutical plant since long ago.The water extract from those plants leaves was reported that it decreased the blood sugar level of rats and rabbits.Murakami et al. reported that corosolic acid contained activated transportation of glucose into cells.We performed a clinical study on efficiency and safety for mild diabetes patients who suffered from decrease of impaired glucose tolerance (IGT) without insulin administration.


Inclusion criteria
	1) More than 110mg of blood sugar level 2) Decrease of IGT and non-insulin dependent diabetes mellitus (NIDDM) 3) Over 20 years old 4) Written agreements with subjects after giving sufficient information on the test to them (informed concept)
Exclusion criteria
	1) Medium and serious DM patients 2) Patients with administration of insulin 3) Patients with previous diseases and complication that can affect the test 4) Patients with pregnancy and expecting pregnancy 5) Patients medically judged unsuitable for the test by the physicians


2-1 Test tablets
	a) LSL extract tablet containing 125mg of LSL extract b) Placebo tablet having similar appearance to the LSL extract tablet
2-2 Schedule of administration
	2 weeks before the test, the blood sugar level of all the subjects was measured. The subjects were randomly allocated in two groups, group1 and group2. Group 1 was administered LSL extract tablets for the first half of eight weeks and then placebo tablets for the second half. Goup2 was administered orally the placebo tablets for the first half and the LSL extract tablets for the second half.
		1. Dose All the subjects were administered 3 tablets of LSL extract/placebo after each meal (9 tablets/day). 2. Combination medicines/therapies If the subjects took/had combination medicines/therapies, the dosage and usage of them were not changed during the test term. 3. Diagnostic descriptions Body weight, blood sugar level, HAIC, fructsamin, insulin, total cholesterol, HDL-cholesterol, leptin, triglyceride, urinary glucose level, the blood pulse, blood pressure, body temperature, total blood protein, GOT, GPT,?-GTP, BUN, CRP, WBC, RBC, Hb, Ht, and urine protein were measured.


		24 subjects, 12 from Aichi Clinic and 12 from Chin Clinic, were registered; 18 males and 6 females with average age of 56.3±9.2, average weight of 70.1±12.5kg, and average BIM (body mass index) score of 25.9±3.8. Two cases of the subjects were excluded from the analysis of efficiency evaluation because one had high blood sugar level (335mg/dl) and an irregular meal intake was found in the other’s patient logbook. The safety evaluation was applied to all the subjects (24 cases)

		No significant difference was observed though non-numerical t- and sequential analysis by scoring the improved level of body weight and the 8 items of the metabolic abnormality index. As a result of ANOVA, it was found that the period and the distinction between group1 and 2 were significant and cross over methods was not formed. No significant difference was seen except for blood sugar level (p<0.01) in the numerical t-analysis on the 8 items of the metabolic abnormality index. A significant decrease of blood sugar level was seen in the 22 subjects, from 153.9±45.5 (before administration) to 133.1±44.5 (after administration). In the 11 subjects of placebo, no significant difference was observed. The mean blood sugar level was 129.1±40.2 (before administration) and 138.7±34.6 (after administration).

		No adverse side effects and abnormal variations on the clinical diagnostic data during the study term were recognized.

1. The water extract of LSL decreased the blood sugar level for the ITG and NIDDM patients.

2. The safety of LSL was confirmed: there were no adverse side effects, or abnormal variation data in the clinical diagnoses.

We are currently looking for volunteers to participate in our clinical research for banaba. Volunteers must reside within Kansai or Kanto regions in Japan. Please contact our office at 0773-25-4411 for more information.