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Corosolic acid is the active substance in banaba, There are 0.1g
of corosolic acid contained in 1kg of dried banaba leaves.
It is known as a kind of triterpene carboxylic acid. Prof. Kazuo
Yamasaki of Hiroshima University (Faculty of Medicine, Institute
of Pharmaceutical Sciences) found that corosolic acid helps to absorb
glucose into cells promptly as insulin does through the research
in Ehrlich ascites tumor cells. That is to say, it activates glucose
transport. Now, the reason why banaba has been called botanical insulin
is made clear.
 
We are conducting a research on corosolic acid in cooperation with
Pampanga Agricultural College, a Philippine national college. So
far, we have found some factors that increase the corosolic acid
content in banaba leaves.
The corosolic acid content in banaba leaves is largely influenced
by the time corosolic acid increases, the age of the tree and the
circumstances. Besides, it was found that stimulation by some kind
of insect increases corosolic acid content.
 We are aiming at developing
more effective banaba leaves by conducting these basic researches.
Researches on corosolic acid at molecule
level are proceeded in cooperation with professors of national and
public universities and colleges.
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We are currently looking for volunteers
to participate in our clinical research for banaba. Volunteers
must reside within Kansai or Kanto regions in Japan. Please
contact our office at 0773-25-4411 for more information.
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